Tissue Therapies Limited is a biomedical technology company that is developing significantly more effective treatments for acute and chronic wound healing applications, including chronic skin ulcers and burns. Tissue Therapies Limited is commercialising VitroGro® ECM, a technology created by cell biology, tissue engineering and protein engineering experts at the Institute of Health and Biomedical Innovation at the Queensland University of Technology. The company also has a licence for commercialisation of various patent families related to wound healing and other therapeutic uses. Tissue Therapies Limited's shares are traded on the Australian, Berlin and Frankfurt stock exchanges.
Shareholder Update 23-04-2015
Tissue Therapies (ASX.TIS) provides an update to shareholders regarding its recent Oral Explanation with the European Medicines Authority’s Committee for Medical Products for Human Use (CHMP) held on 25 March 2015 in London.... More
Shareholder Questions and Answers 23-04-2015
This Question and Answers document provides detailed technical information on the product, the recent EMA oral explanation and the EU regulatory process to date. Please also refer to the Shareholder Updated dated 23 April 2015.... More
Global Webpage Updates 20-04-2015
The Tissue Therapies website is currently being updated with new information in a series of global changes that include but are not limited to changes to the product information page, partner information, staff and publications sections of the website. We apologies in advance for any inadvertent downtime of the website during these updates.... More
Publications Update 17-04-2015
Tissue Therapies Limited and its research partners are preparing several peer reviewed publications. These papers include further characterisation of the mode of actions of the VitroGro® protein and a methodology paper for the health economic model.
We are also reporting a well-conducted cross-trial... More
Board and Management Changes 07-04-2015
The Board of Tissue Therapies Limited announces that the Company’s CEO, Dr Steven Mercer, has resigned from the Company effective as of today. The Board has appointed Mr Nigel Johnson, the current Operations Director as acting CEO.
The current Chairman, Mr Roger Clarke has announced that he will stand down as... More
Tissue Therapies Limited has identified that there is a significant need in wound care for improving the outcome of hard to heal wounds. Hard to heal wounds are defined as wounds that have not respond to standard therapy in an orderly and timely manner . This type of delayed healing occurs in a variety of wound types (venous leg ulcers, arterial leg ulcers, mixed leg ulcers, diabetic foot ulcers and pressure ulcers) [1,2,3].
Treatment of hard to heal wounds is demanding on both patients and healthcare providers, with significant financial impact on the healthcare systems and the patients quality of life. For example, conservative costs to the UK National Health Service (NHS) are estimated at £2-3 billion per year. In the United States hard to heal wounds effect 6.5 million patients and is estimated to cost in excess of US$25 billion annually .
In Germany, according to cautious estimates, approximately 3-4 million people suffer from hard to heal wounds and costs associated are high for the Statutory Health Insurance (SHI) funds, the economy and patients . The average annual cost to the SHI per patient for the treatment of venous leg ulcers alone was estimated at €7630.70 and the annual cost to the patient was estimated at €1027 .
Hard to heal wounds are associated with a damaged extracellular matrix (ECM). A functional ECM is required for normal healing to proceed. VitroGro® ECM is an ECM replacement that improves wound care and promotes healing.
In 2007, a UK hospital audit found that the drivers behind such high costs were;
- The relatively high incidence of non-healing wounds (1 in 4 wounds had been non-healing for at least six months);
- The prevalence of infections associated with non-healing wounds, resulting in longer hospital related care;
- Nursing time, which was associated 33-41% of the total cost of care and the cost of wound dressings, which were associated with 17-22% of the total cost of care.
VitroGro® ECM is a new treatment for hard to heal wounds that is used in conjunction with standard care including moist wound dressing and compression. We see opportunities to have significant impact in wound care markets in Asia, Australia, Canada, Europe, New Zealand, the United States and other markets experiencing the economic burden of wound care. [learn more]
 Vowden P. Hard to heal wounds made easy. Wounds International 2011
 Srinivasaiah N. et al. A point prevalence survey of wounds in the North East of England. J. Wound Care 2007
 Vowden KR. and Vowden P. The prevalence, management, equipment provision and outcomes for patients with pressure ulceration identified in a wound care survey with one English health care district. J. Tissue Viability 2009.
 Harding K and Queen D. Chronic wounds and their management and prevention is a significant public health issue. Int. Wound J. 2010
 Purwins S et al. Cost of illness of chronic leg ulcers in Germany Int. Wound J. 2010
 Drew P et al. The cost of wound care for a local population in England. Int. Wound J. 2007